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**Increase in N.Z Post Delivery Rates** July 2023
Due to inflationary pressures, new Rates are as follows:
Economy Rate, tracked @ $8.
Courier Rate, tracked @ $10. (*Fastest Delivery)
Rural Delivery Rate @ plus+ $5.50
Due to N.Z Post price increases, you might like to consider *Parcel Collect to avoid the extra Rural Delivery Costs for some Customers.
*R.18 New Zealand Customers Only. Proof of Age Required.
If you do not Verify Age, we will not process your Order.
Payment via Online Banking. N.Z Post track & trace.
*Price List & Specials - HERE
*NorthlandSalvia Lite: view Previews of all our Primary content: HERE
Contact: northlandsalvia@gmail.com
*Special: 1 g FREE! Salvia tea/Smokable dried herb when you spend $25. on a Marali Product.
Marali offers great therapeutic potential, & may be particularly effective at alleviating Anxiety in this Age of Covid.
Marali 30x strength, liquid extract, Oil, Tincture, VG-Juice herbal remedy, may assist as: a Sedative, analgesic, anti inflammatory, nicotine tobacco cessation aid, promote Emotional Balance, Anti anxiety, Anti depressant.
Marali may bring relief to those suffering the debilitating effects of Anxiety, often accompanying withdrawal - detox from Opioids, Methamphetamine, Cocaine, Cannabis, Synthetics, Nicotine - Tobacco & other drugs of abuse.
Tweaking, when the Meth User has come to the end of a meth binge, and the drug is no longer providing the user with the desired rush or high, can be a challenging time, not only for the user, but their families. The Meth User will feel intense cravings and desperation that can no longer be satisfied. It is at this point that psychotic symptoms may manifest and the user begins to suffer from delusions, hallucinations, and other altered perceptions. Many will turn to blackmarket sourced pharmaceuticals such as diazepam to cushion the effects.
Nicotine-Tobacco addiction is a scourge in our community, responsible for early death, & many negative health outcomes, particularly in indigenous communities.
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Marali binds potently to the Nicotinic Receptor, offering therapeutic potential as a smoking cessation aid.
Nicotine dependence causes distress. Nicotine withdrawal symptoms include depressed mood, stress, anxiety, irritability, difficulty concentrating, and sleep disturbances.
Mild nicotine withdrawal symptoms are measurable in unrestricted smokers, who experience normal moods only as their blood nicotine levels peak, with each cigarette.
On quitting, withdrawal symptoms worsen sharply, then gradually improve to a normal state. This is a crucial time for the person attempting to quit smoking, with many conceding to the pangs of tobacco addiction, & so the cycle of addiction begins anew.
Depression: Studies demonstrate that depression and chronic stress exposure cause atrophy of neurons in cortical and limbic brain regions implicated in depression, and brain imaging studies demonstrate altered connectivity and network function in the brains of depressed patients.
Studies of the neurobiological basis of the these alterations have focused on both the principle, excitatory glutamate neurons, as well as inhibitory GABA interneurons.
They demonstrate structural, functional, and neurochemical deficits in both major neuronal types that could lead to degradation of signal integrity in cortical and hippocampal regions.
The molecular mechanisms underlying these changes have not been identified but are thought to be related to stress induced excitotoxic effects in combination with elevated adrenal glucocorticoids and inflammatory cytokines, (as well as other environmental factors).
Studies are beginning to demonstrate important sex differences and together with genomic studies are starting to reveal mechanistic domains of overlap and uniqueness with regards to risk and pathophysiological mechanisms with schizophrenia and bipolar disorder.
These studies also implicate GABA and glutamate dysfunction as well as immunologic mechanisms.
' While current antidepressants have significant time lag and efficacy limitations, new, rapid acting agents that target the glutamate and GABA systems address these issues and offer superior therapeutic interventions for this widespread and debilitating disorder.' Duman et al., 2019
In this Age of Covid, Depression & Anxiety Disorders in the general population are flourishing.
Marali may bring relief to Aspergers & High Functioning Autistics, highly sensitive, they may be overwhelmed by sensory stimulation, presenting as Anxiety Disorders. Often gifted with a 'Super Power' but crippled socially, they may fail to reach their full potential.
GABA/Glutamate levels are decreased in adolescents with (H.F.A) high-functioning autism. These changes imply altered metabolic regulation in high-functioning autism. These results imply that imbalanced neurotransmitter levels of excitation and inhibition are associated with HFA in adolescents. Drenthen et al, 2016.
Studies have indicated the potential role of GABAergic System Dysfunction in Autism Spectrum Disorders
" Gamma-aminobutyric acid (GABA) is a pivotal inhibitory neurotransmitter
in the CNS. GABAergic inhibitory neurotransmission is critical for the
regulation of brain rhythm and spontaneous neuronal activities during
brain development. The imbalance between excitation and GABAergic
inhibition might be consequently contributed to the dysfunction of the
CNS GABAergic system. Increasing evidence has shown that dysfunction of
inhibitory neurotransmission is implicated in neurophysiological
mechanisms of neuropsychiatry disorders, including schizophrenia,
depression, and anxiety " Zhao et al, 2022
Some clinical manifestations (such as cognitive dysfunctions, attention deficits, etc.) have also been shown to emerge after abnormalities in the GABAergic system accompanied with concomitant diseases, that include Alzheimer’s disease (AD), Parkinson’s disease (PD), Autism spectrum disorder (ASD), Schizophrenia, etc. Zhang et al.2021.
Back Story:
Marali is an Indigenous Australian Aboriginal term for Spiritual Healing & Bush Medicines.
Historically, with the advent of the burgeoning British Empire & it's massive Colonial ambitions, inevitably, many of the Sacred Healing Plants of Australia were transplanted to Aotearoa New Zealand, where they thrived with naked abandon, sometimes overtaking our own native flora & coming to be perceived as invasive weeds.
Our Marali Liquid Extract is a potent, 30x strength, 5 ml, 20 ml, 100 ml proprietary blend of those Original Australian 'Outback' herbs, designed for sublingual tincture dosing, Olive Oil, & can also be used in VG form, VG-Juice.
Marali may assist those seeking a natural plant based herbal remedy, with analgesic, sedative, & anti inflammatory effects.
This herbal remedy may also provide relief for Insomnia, Anxiety, Depression, & promote emotional balance.
Emotional balance is the ability of the mind and body to maintain equilibrium and flexibility in the face of challenge and change.
In liquid extract form, Marali herbal remedy may have the efficacy of some of the anti anxiety products available, but without any of the associated dependency issues & problematic side effects.
In liquid extract form, Marali herbal remedy may have the efficacy of some of the nicotine tobacco cessation products available but without any of the associated side effects.
Marali is 100% Natural, Legal, NOT Restricted or Prohibited, & DOES NOT cause drowsiness.
*Marali 30x Liquid Extract can also be used to make your own Lozenges using a basic toffee recipe too. Add some Hansells Natural Flavouring from the baking section of your local supermarket & you are good to go!
NEW! 5 ml Sampler, 30x strength, Marali Liquid Extract @ $25. *plus p & p.
20 ml, 30x strength, Marali Liquid Extract @ $99. *plus p & p.
*20 ml Special - get an extra 5 ml (25 ml) FREE! Save $25. *25 ml Special = *Sold Out*
100 ml, 30x strength, Marali Liquid Extract @ $399. *plus p & p. FREE POST! Save $ *Economy, not incl Courier & Rural Upgrade.
*Bulk Buy & Save! 500 ml & 1 Litre bottles of all our liquid extract herbal remedies range, available at Discounted Prices - Prices on enquiry. Ts & Cs apply.
Available as a 30x strength, Olive Oil based liquid extract, OR a VG - Vegetable Glycerine based liquid extract.
Olive Oil & VG-Juice Marali 30x Liquid Extracts.
*R.18 N.Z Customers Only. Proof of Age Required.
Payment via Online Banking. N.Z Post track & trace.
Contact: northlandsalvia@gmail.com
Research Papers RE: the Potential to treat Movement Disorders (e.g Parkinsons, Tourettes) by targeting the Nicotinic Receptor:
Role for the nicotinic cholinergic system in movement
disorders; therapeutic implications.
Mounting evidence in experimental models indicate that nicotine and nAChR drugs improve motor deficits (summarized in Table 1) and may be useful for attenuating movement disorders in the clinic (summarized in Table 2). As well, nAChR drugs hold promise as neuroprotectants against neuronal degeneration as occurs in Parkinson’s disease
Potential Therapeutic Application for Nicotinic
Receptor Drugs in Movement Disorders
' Accumulating data from preclinical studies and clinical trials suggest that drugs targeting CNS cholinergic systems may be useful for symptomatic treatment of various movement disorders. '
' there is some evidence that nicotine and other general nAChR agonists may be useful in Tourette’s syndrome and ataxia '
